%0 Journal Article
%T Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model
%A Emi Tanaka
%A Jin Tokunaga
%A Kenji Ogata
%A Mitsuhiro Kai
%A Nao Setoguchi
%A Norito Takamura
%A Susumu Chiyotanda
%A Yasuyuki Kourogi
%J Archive of "Theoretical Biology & Medical Modelling".
%D 2017
%R 10.1186/s12976-017-0054-9
%X When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trough (population mean method predicted value [PMMPV]) calculated using the population mean method (PMM) often deviate from the effective concentration range. In this study, we used the generalized linear mixed model (GLMM) for initial dose planning to create a model that accurately predicts Css-trough, and subsequently assessed its prediction accuracy
%K Vancomycin
%K Therapeutic drug monitoring
%K Initial dose planning
%K Generalized linear mixed model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385004/