%0 Journal Article
%T Vibrational spectroscopic analysis of hydroxyapatite in HYP mice and individuals with X-linked hypophosphatemia
%A Carolyn M. Macica
%A Eva Amenta
%A Helen E. King
%A Holger Petermann
%A Steven M. Tommasini
%A Vuk Uskokovi£¿
%J Archive of "Therapeutic Advances in Chronic Disease".
%D 2018
%R 10.1177/2040622318804753
%X X-linked hypophosphatemia (XLH) is the most common form of familial phosphate-wasting disorders, due to an inactivating mutation in the phosphate-regulating neutral endopeptidase, X-linked gene. Persistent osteomalacia, enthesophytes, osteophytes, degenerative arthritis and dental abscesses/periodontal disease dominate the adult disorder. However, the impact of insufficient phosphate on hydroxyapatite composition, the major inorganic component of bone and teeth, is unknown in individuals with XLH
%K carbonate
%K cortical bone
%K dentin
%K hydroxyapatite composition
%K phosphate
%K XLH
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348532/