%0 Journal Article
%T The Role of Human Platelet Preparation for Toll-Like Receptors 2 and 4 Related Platelet Responsiveness
%A Angela Koessler
%A Anna Kobsar
%A Juergen Koessler
%A Katja Weber
%A Marius Niklaus
%A Markus Boeck
%A Sabine Kuhn
%J Archive of "TH Open: Companion Journal to Thrombosis and Haemostasis".
%D 2019
%R 10.1055/s-0039-1685495
%X Background £żLike immune cells, platelets express the repertoire of toll-like receptors (TLR), among them TLR2 and TLR4, which are important for the recognition of bacterial patterns. Receptor-mediated functional effects in platelets have been investigated, but reliable conclusions are tampered due to heterogeneous study designs with variable platelet preparation methods. This study compares TLR2- and TLR4-dependent platelet responsiveness in platelet-rich plasma (PRP) and in washed platelets (WPs)
%K toll-like receptor
%K lipopolysaccharides
%K chemokine
%K platelet preparation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524919/