%0 Journal Article
%T HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline
%A Ashwin Balagopal
%A David L. Thomas
%A Gregory D. Kirk
%A Jacquie Astemborski
%A Jeffrey Quinn
%A Shruti H. Mehta
%J Archive of "Pathogens and Immunity".
%D 2017
%R 10.20411/pai.v2i1.183
%X We have previously reported that persons co-infected with HIV and hepatitis C virus (HCV) had liver disease stages similar to HIV-uninfected individuals who were approximately 10 years older. Insulin-like growth factor 1(IGF-1) levels have long been known to decline with advancing age in humans and non-humans alike. We examined whether HIV infection affects the expected decline in IGF-1 in persons with chronic hepatitis C virus (HCV) infection and if that alteration in IGF-1 decline contributes to the link between HIV, aging, and liver disease progression
%K IGF-1
%K HIV-1
%K Hepatitis C
%K Fibrosis
%K Liver
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425162/