%0 Journal Article
%T Impact of Tigecycline Versus Other Antibiotics on the Fecal Metabolome and on Colonization Resistance to Clostridium difficile in Mice
%A Alex Polinkovsky
%A Curtis J. Donskey
%A David Kraft
%A Kelly Hurless
%A Robin L.P. Jump
%J Archive of "Pathogens and Immunity".
%D 2017
%R 10.20411/pai.v2i1.159
%X The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics. We used a mouse model to compare the effects of tigecycline versus other commonly used antibiotics on colonization resistance to C. difficile and on the metabolic functions of the intestinal microbiota
%K Tigecycline
%K Clostridium difficile
%K ceftriaxone
%K piperacillin/tazobactam
%K linezolid
%K metabolomics
%K colonization resistance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315001/