%0 Journal Article
%T Characterisation of P-glycoprotein-9.1 in Haemonchus contortus
%A Hua Che
%A Pablo Godoy
%A Robin N. Beech
%A Roger K. Prichard
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1317-8
%X The existence nematodes of veterinary importance such as Haemonchus contortus resistant to anthelmintic drugs, including the macrocyclic lactones, has become a major concern in animal health. Macrocyclic lactone resistance in H. contortus seems to be multigenic including the active efflux of these drugs by P-glycoproteins, members of the ABC transporter family, present in this parasite. The goals of the present work were to determine the activity of H. contortus P-glycoprotein 9.1 (Hco-PGP-9.1) and its interaction with the avermectins, ivermectin, abamectin, and also the milbemycin, moxidectin. Additionally, the localisation of Hco-PGP-9.1 was sought in adult worms
%K Macrocyclic lactone resistance
%K P-glycoprotein
%K Transport studies
%K Heterologous expression system
%K Protein localisation
%K Ivermectin
%K Abamectin
%K Moxidectin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730751/