%0 Journal Article
%T Oxadiazole-2-oxides may have other functional targets, in addition to SjTGR, through which they cause mortality in Schistosoma japonicum
%A Bainian Feng
%A Chuan-Xin Yu
%A Gu-Ping Wang
%A Hong Gao
%A Huan Luo
%A Jie Wang
%A Li-Jun Song
%A Qian Liu
%A Shuang Shen
%A Wei Zhang
%A Wen-Hua Fan
%A Wen-Long Wang
%A Xu-Ren Yin
%A Yi Jin
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1301-3
%X Schistosomiasis is one of the worldĄŻs major public health problems. Besides praziquantel (PZQ), there is currently no other effective treatment against schistosomiasis. The development of new antischistosomal agents to curb the emergence of PZQ resistance should be a high priority. Oxadiazole-2-oxides have been identified as potential antischistosomal reagents, with thioredoxin glutathione reductase (TGR) being one of their molecular targets
%K Schistosoma japonicum
%K Oxadiazole-2-oxide
%K Antischistosomal activity
%K Structure-activity relationship (SAR)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721062/