%0 Journal Article
%T In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis
%A Ana L. Legarda-Ceballos
%A Antonio Muro
%A Arturo San Feliciano
%A Bel¨¦n Vicente
%A Esther del Olmo
%A Jose Rojas-Caraballo
%A Julio L¨®pez-Ab¨˘n
%A Luis A. Bustos
%A Pedro Fern¨˘ndez-Soto
%A Ricardo Escarcena
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1648-5
%X Strongyloidiasis is a parasitic disease widely present in tropical and subtropical areas. Strongyloides stercoralis represents the main species that infects human beings. Ivermectin is the current drug of choice; however, issues related with treatment failure in patients with diabetes or infected with T-lymphotropic virus-1 make the identification of new molecules for alternative treatment a priority. In the present study, the activity of sphingosine-related aminoalcohol and diamine were evaluated against Strongyloides venezuelensis third-stage larva (L3) cultures and experimental infections in mice
%K Strongyloidiasis
%K Treatment
%K Alkaneaminoalcohol
%K Alkanediamine
%K Anthelmintics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924291/