%0 Journal Article
%T Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis
%A Albert Schriefer
%A Am¨¦lia Ribeiro de Jesus
%A Andr¨¦a Santos Magalh£¿es
%A C¨¦lia Maria Vieira Vendrame
%A Edgar Marcelino de Carvalho
%A Hiro Goto
%A Luana Dias de Souza
%A Luiz Henrique Guimar£¿es
%A M¨¢rcia Dias Teixeira Carvalho
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1619-x
%X American tegumentary leishmaniasis (ATL) in Brazil is mostly caused by Leishmania (Viannia) braziliensis, with known forms of the disease being cutaneous (CL), mucosal (ML) and disseminated (DL) leishmaniasis. The development of the lesion in ATL is related both to the persistence of the Leishmania in the skin and to the parasite-triggered immune and inflammatory responses that ensue lesions. In this context one factor with expected role in the pathogenesis is insulin-like growth factor (IGF)-I with known effects on parasite growth and healing and inflammatory processes. In the present study, we addressed the effect of IGF-I on intracellular amastigote isolates from CL, ML and DL patients within human macrophage and we evaluated the IGF-I and IGF-binding protein-3 (IGFBP3) serum levels in patients presenting different clinical forms and controls from the endemic area
%K Leishmania braziliensis
%K Tegumentary leishmaniasis
%K THP-1
%K IGF-I level
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902932/