%0 Journal Article
%T Cytotoxic and apoptosis-inducing effects of wildtype and mutated Hydra actinoporin-like toxin 1 (HALT-1) on various cancer cell lines
%A Crystale Siew Ying Lim
%A Dek Shen Liew
%A Jung Shan Hwang
%A Lionel L.A. In
%A Michelle Yee Mun Teo
%A Paul Etim Effiong
%A Teng Jia Ng
%J Archive of "PeerJ".
%D 2019
%R 10.7717/peerj.6639
%X Hydra actinoporin like toxin -1 (HALT-1), is a small 18.5 kDa pore forming toxin derived from Hydra magnipapillata which has been shown to elicit strong haemolytic and cytolytic activity when in contact with cell membranes. Due to its cytotoxic potency, HALT-1 was further investigated for its potential as a toxin moiety candidate in immunotoxin developmental efforts, ideally as a form of targeted therapy against cancer
%K Cytotoxicity
%K Immunotoxin
%K Apoptosis
%K Pore-forming toxins
%K Hydra actinoporin
%K Cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500716/