%0 Journal Article %T Introduction %J Archive of "Pediatric Quality & Safety". %D 2018 %R 10.1097/pq9.0000000000000075 %X The introductory paragraph of anything relating to pediatric sepsis has a familiar refrain about it. It goes something like¡­ Pediatric sepsis is common, is responsible for significant morbidity and mortality, and is the leading cause of pediatric deaths worldwide¡ªstriking down both healthy and at-risk children.1¨C4 There is a large evidence-based therapeutic arsenal available to treat sepsis and reverse shock, with contemporary consensus guidelines¡ªand ample data to show that increased adherence to such guidelines significantly improves outcomes, including survivorship.5¨C9 Pediatric sepsis is a multi-billion dollar problem annually in the United States¡ªwith costs that rise year after year.10 Not surprisingly, health systems are experiencing increased levels of mandatory performance and outcome reporting from national and state regulatory bodies and looming pay-for-performance metrics. %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132752/