%0 Journal Article
%T PvGAMA reticulocyte binding activity: predicting conserved functional regions by natural selection analysis
%A Darwin A. Moreno-P¨¦rez
%A Diego Garz¨®n-Ospina
%A Heidy D. Ortiz-Su¨¢rez
%A Johanna Forero-Rodr¨ªguez
%A Luis A. Baquero
%A Manuel A. Patarroyo
%J Archive of "Parasites & Vectors".
%D 2017
%R 10.1186/s13071-017-2183-8
%X Adhesin proteins are used by Plasmodium parasites to bind and invade target cells. Hence, characterising molecules that participate in reticulocyte interaction is key to understanding the molecular basis of Plasmodium vivax invasion. This study focused on predicting functionally restricted regions of the P. vivax GPI-anchored micronemal antigen (PvGAMA) and characterising their reticulocyte binding activity
%K Adhesin protein
%K Plasmodium vivax
%K Genetic diversity
%K Conserved functional region
%K Reticulocyte binding activity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438544/