%0 Journal Article
%T An investigation into the potential effects of infrapopulation structure and other sources of sampling error, on population genetic studies of the transmission of Schistosoma japonicum (Trematoda: Digenea)
%A Guan-Nan Huo
%A Hong-Bin He
%A Liang Liu
%A Stephen W. Attwood
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1454-0
%X Schistosoma japonicum remains a major challenge to human and animal health. Earlier microsatellite-based studies reported possible definitive-host-specific private alleles within S. japonicum, opening the possibility that different definitive hosts might harbour different parasite strains. Previous investigations have also detected near-identical multilocus genotypes in populations of adult worms - possibly the result of mutations occurring during the asexual (intramolluscan) phase of clonal expansion. Research has also revealed extensive deviations from Hardy-Weinberg Proportions (HWP) and conflicting results among studies. The present study was performed to examine some of the potential effects of infrapopulation structure on microsatellite-based studies of the transmission ecology of S. japonicum. Potential sources of bias considered included organotropic distribution of worms, non-random mating and corrections for clonal expansion
%K Schistosoma japonicum
%K Microsatellite
%K Infrapopulation
%K Population genetics
%K Hardy-Weinberg
%K Sampling bias
%K Organotropic
%K Mating
%K Genetic differentiation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802887/