%0 Journal Article
%T Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice
%A Bin Zhan
%A Dapeng Qiu
%A Hui Zhang
%A Huihui Li
%A Jilong Shen
%A Liang Chu
%A Nan Li
%A Qiang Fang
%A Shushu Wang
%A Wenxin He
%A Xiaodi Yang
%A Xingzhi Chen
%A Yongkun Wan
%J Archive of "Parasites & Vectors".
%D 2017
%R 10.1186/s13071-017-2162-0
%X Sepsis is a life-threatening complication of an infection and remains one of the leading causes of mortality in surgical patients. Bacteremia induces excessive inflammatory responses that result in multiple organ damage. Chronic helminth infection and helminth-derived materials have been found to immunomodulate host immune system to reduce inflammation against some allergic or inflammatory diseases. Schistosoma japonicum cystatin (Sj-Cys) is a cysteine protease inhibitor that induces regulatory T-cells and a potential immunomodulatory. The effect of Sj-Cys on reducing sepsis inflammation and mortality was investigated
%K Cystatin
%K Schistosoma japonicum
%K Sepsis
%K Cecal ligation and puncture
%K Immunomodulation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422996/