%0 Journal Article %T Schistosoma japonicum HSP60-derived peptide SJMHE1 suppresses delayed-type hypersensitivity in a murine model %A Chaoming Mao %A Chengcheng Xu %A Deyu Chen %A Hongchang Ni %A Jun Wang %A Liang Shi %A Xiao Mou %A Xuefeng Wang %A Yong Liang %A Yuepeng Zhou %A Yuting Su %J Archive of "Parasites & Vectors". %D 2016 %R 10.1186/s13071-016-1434-4 %X Parasite-derived molecules with immunomodulatory properties, which have been optimised during host-parasite co-evolution, exhibit potential applications as novel immunotherapeutics. We have previously demonstrated that Schistosoma japonicum HSP60-derived peptide SJMHE1 induces CD4+CD25+ regulatory T-cells (Tregs) and that adoptively transferred SJMHE1-induced CD4+CD25+ Tregs inhibit delayed-type hypersensitivity (DTH) in mice. However, multiple concerns regarding this method render this treatment unsuitable. To gain further insights into the potential effects of SJMHE1, we used ovalbumin (OVA)-induced DTH and evaluated the effect of SJMHE1 on DTH mice %K Schistosoma japonicum-derived peptide %K SJMHE1 %K Suppress %K Delayed-type hypersensitivity %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789290/