%0 Journal Article
%T Paratransgenesis to control malaria vectors: a semi-field pilot study
%A Abdoulaye Diabat¨¦
%A Aida Capone
%A Alessia Cappelli
%A Anastasia Accoti
%A Claudia Damiani
%A Elisabetta Petraglia
%A Giulia Peruzzi
%A Guido Favia
%A Irene Ricci
%A Luca Facchinelli
%A Maria Vittoria Mancini
%A Mario Tallarita
%A Matteo Picciolini
%A Matteo Valzano
%A Paolo Rossi
%A Roberta Spaccapelo
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1427-3
%X Malaria still remains a serious health burden in developing countries, causing more than 1 million deaths annually. Given the lack of an effective vaccine against its major etiological agent, Plasmodium falciparum, and the growing resistance of this parasite to the currently available drugs repertoire and of Anopheles mosquitoes to insecticides, the development of innovative control measures is an imperative to reduce malaria transmission. Paratransgenesis, the modification of symbiotic organisms to deliver anti-pathogen effector molecules, represents a novel strategy against Plasmodium development in mosquito vectors, showing the potential to reduce parasite development. However, the field application of laboratory-based evidence of paratransgenesis imposes the use of more realistic confined semi-field environments
%K Asaia
%K Anopheles
%K Paratransgenesis
%K Large cages trials
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787196/