%0 Journal Article
%T The use of one-stage meta-analytic method based on individual participant data for binary adverse events under the rule of three: a simulation study
%A Chang Xu
%A Ke Ju
%A Liang-Liang Cheng
%A Rui-Lie Cai
%J Archive of "PeerJ".
%D 2019
%R 10.7717/peerj.6295
%X In evidence synthesis practice, dealing with binary rare adverse events (AEs) is a challenging problem. The pooled estimates for rare AEs through traditional inverse variance (IV), Mantel-Haenszel (MH), and Yusuf-Peto (Peto) methods are suboptimal, as the biases tend to be large. We proposed the ˇ°one-stageˇ± approach based on multilevel variance component logistic regression (MVCL) to handle this problem
%K IPD meta-analysis
%K Evidence synthesis methods
%K Multilevel logistic
%K Rule of three
%K Binary rare adverse event
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347966/