%0 Journal Article
%T Echinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation
%A Ana L¨ªa Ramos
%A Ana Maite Folle
%A Ana Mar¨ªa Ferreira
%A Betina C¨®rsico
%A Eduardo S. Kitano
%A In¨¦s Corraliza
%A Leo K. Iwai
%A Valeria Silva-¨¢lvarez
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1350-7
%X Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The functions of EgAgB in parasite biology remain unclear. It may play a role in the parasite¡¯s lipid metabolism since it carries host lipids that E. granulosus is unable to synthesise. On the other hand, there is evidence supporting immuno-modulating activities in EgAgB, particularly on innate immune cells. Both hypothetical functions might involve EgAgB interactions with monocytes and macrophages, which have not been formally analysed yet
%K Echinococcus granulosus
%K Antigen B
%K HLBP
%K Cell binding
%K Lipoproteins
%K Monocytes
%K Macrophages
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743400/