%0 Journal Article
%T Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)
%A Fa-Cai Li
%A Fang-Yuan Yin
%A James B. Lok
%A Jun-Long Zhao
%A Li He
%A Min Hu
%A Pasi K. Korhonen
%A Robin B. Gasser
%A Rui Zhou
%A Wen-Da Di
%A Yan-Qin Zhou
%J Archive of "Parasites & Vectors".
%D 2016
%R 10.1186/s13071-016-1351-6
%X Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) and activates protein kinases of the AGC family, plays critical roles in regulating biology processes, such as metabolism, growth, development and survival. In the free-living nematode Caenorhabditis elegans, PDK-1 is a key component of the insulin-like signalling pathway, regulating the entry into and exit from dauer (arrested development). Although it is proposed that similar molecular mechanisms control the transition from the free-living to the parasitic stages of nematodes, nothing is known about PDK-1 in Haemonchus contortus, a socioeconomically important gastric nematode of ruminants
%K Haemonchus contortus
%K Transgenesis
%K Development
%K pdk-1 gene
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741024/