%0 Journal Article %T Rational Design, Synthesis and Evaluation of ¦Ã-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform %A Adolfo Marican %A Esteban F. Dur¨¢n-Lara %A Fabi¨¢n Avila-Salas %A Jorge Villase£¿or %A Mauricio Arenas-Salinas %A Natalia Fuentealba %A Oscar Vald¨¦s %A Sergio Wehinger %A Ver¨®nica Carrasco-S¨¢nchez %A Yerko Argando£¿a %J Archive of "Pharmaceutics". %D 2018 %R 10.3390/pharmaceutics10010030 %X This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing ¦Ã-cyclodextrin (¦Ã-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of ¦Ã-cyclodextrin (¦Ã-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing ¦Ã-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of ¦Ã-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and ¦Ã-CDHSA was mainly produced with the ¦Ã-CDs linked to the hydrogels. Thus, the unique structures and properties of ¦Ã-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN %K drug delivery %K crosslinking %K prednisone %K cyclodextrins %K swelling %K accumulative release %K thermogravimetric analysis %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874843/