%0 Journal Article
%T Rational Design, Synthesis and Evaluation of 污-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform
%A Adolfo Marican
%A Esteban F. Dur芍n-Lara
%A Fabi芍n Avila-Salas
%A Jorge Villaseˋor
%A Mauricio Arenas-Salinas
%A Natalia Fuentealba
%A Oscar Vald谷s
%A Sergio Wehinger
%A Ver車nica Carrasco-S芍nchez
%A Yerko Argandoˋa
%J Archive of "Pharmaceutics".
%D 2018
%R 10.3390/pharmaceutics10010030
%X This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing 污-cyclodextrin (污-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of 污-cyclodextrin (污-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing 污-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of 污-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and 污-CDHSA was mainly produced with the 污-CDs linked to the hydrogels. Thus, the unique structures and properties of 污-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN
%K drug delivery
%K crosslinking
%K prednisone
%K cyclodextrins
%K swelling
%K accumulative release
%K thermogravimetric analysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874843/