%0 Journal Article
%T Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress
%A Anna Maria Fadda
%A Carla Caddeo
%A Claudia Carbone
%A Elvira Escribano-Ferrer
%A Iris Usach
%A Jos¨¦ Esteban Peris
%A Maria Letizia Manca
%A Maria Manconi
%A Maryam Rezvani
%A Octavio Diez-Sales
%J Archive of "Pharmaceutics".
%D 2019
%R 10.3390/pharmaceutics11010013
%X The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit£¿ L100), a water-soluble prebiotic fibre (Nutriose£¿ FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit£¿ and Nutriose£¿ on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan£¿ technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation
%K Eudragit
%K Nutriose
%K phospholipid vesicles
%K antioxidant
%K intestinal wound healing
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358973/