%0 Journal Article
%T The frequency of SLCO1B1*5 polymorphism genotypes among Russian and Sakha (Yakutia) patients with hypercholesterolemia
%A Andrej Vladimirovich Grachev
%A Dmitrij Alekseevitch Sychev
%A Grigorij Nikolaevich Shuev
%A Jana Valer¡¯evna Chertovskih
%A Nadezhda Romanovna Maksimova
%A Ol¡¯ga Aleksandrovna Syrkova
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2016
%R 10.2147/PGPM.S99634
%X Statins are the most commonly prescribed medicines for treatment of hypercholesterolemia. At the same time, up to 25% of patients cannot tolerate or have to discontinue the statin therapy due to statin-induced myopathy. In a majority of cases, statin-induced myopathy is attributed to SLCO1B1 gene polymorphism. The strongest association between statin-induced myopathy and SLCO1B1 gene polymorphism was described for simvastatin. Our research was focused on the frequency of SLCO1B1*5 genetic variant in the Russian population and in the native population of Sakha (Yakutia)
%K Russian
%K Sakha (Yakutia)
%K pharmacogenetics
%K SLCO1B1
%K statins
%K myopathy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889090/