%0 Journal Article
%T Curcumin-Artemisinin Coamorphous Solid: Xenograft Model Preclinical Study
%A Ashwini Nangia
%A Durga Bhavani Konga
%A Kuthuru Suresh
%A M. K. Chaitanya Mannava
%A Manish Kumar Bommaka
%J Archive of "Pharmaceutics".
%D 2018
%R 10.3390/pharmaceutics10010007
%X Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited superior dissolution and pharmacokinetic behavior compared to pure CUR, which is practically insoluble in water. CUR-ART coamorphous solid showed two fold higher bioavailability than CUR-PYR cocrystal (at 200 mg/kg oral dose). Moreover, in simulated gastric and intestinal fluids (SGF and SIF), CUR-ART is stable up to 3 and 12 h, respectively. In addition, CUR-PYR and CUR-ART showed no adverse effects in toxicology studies (10 times higher dose at 2000 mg/kg). CUR-ART showed higher therapeutic effect and inhibited approximately 62% of tumor growth at 100 mg/kg oral dosage of CUR in xenograft models, which is equal to the positive control drug, doxorubicin (2 mg/kg) by i.v. administration
%K curcumin
%K artemisinin
%K coamorphous
%K cocrystal
%K stability
%K bioavailability
%K xenograft
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874820/