%0 Journal Article
%T The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction
%A Dmitry Alekseevich Sychev
%A Elena Anatolievna Grishina
%A Evgeny Alekseevich Bryun
%A Ludmila Mikhailovna Savchenko
%A Mikhail Sergeevich Zastrozhin
%A Valery Valerieevich Smirnov
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2016
%R 10.2147/PGPM.S110385
%X Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse
%K haloperidol
%K biotransformation
%K CYP2D6
%K side effects
%K alcohol addiction
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028170/