%0 Journal Article
%T Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling
%A Adham Sameer A. Bardeesi
%A Ai He
%A Caiqin Wang
%A Lina Zhou
%A Lu Zhao
%A Mei Shang
%A Tingjin Chen
%A Xinbing Yu
%A Xuerong Li
%A Yan Huang
%A Ye Li
%A Yinjuan Wu
%A Yu Jian
%A Zhaolei Li
%A Zhiyue Lv
%J Archive of "Parasites & Vectors".
%D 2017
%R 10.1186/s13071-017-2082-z
%X Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and is a component of excretory and secretory products (CsESPs). Phospholipase A2 is well known for its role in liver fibrosis and inhibition of tumour cells. The JNK signalling pathway is involved in hepatic stellate cells (HSCs) activation. Blocking JNK activity with SP600125 inhibits HSCs activation. In a previous study, the protein CssPLA2 was expressed in insoluble inclusion bodies. Therefore, it¡¯s necessary to express CssPLA2 in water-soluble form and determine whether the enzymatic activity of CssPLA2 or cell signalling pathways is involved in liver fibrosis caused by clonorchiasis
%K Phospholipase A2
%K Clonorchis sinensis
%K Enzyme
%K Liver fibrosis
%K Cholangiocarcinoma
%K JNK signalling pathway
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353963/