%0 Journal Article
%T Soluble Markers of Immune Activation Differentially Normalize and Selectively Associate with Improvement in AST, ALT, Albumin, and Transient Elastography During IFN-Free HCV Therapy
%A Amy Hirsch
%A Anita Compan
%A Anita Moreland
%A Brianna Fuller
%A Carey L. Shive
%A Daniel L. Popkin
%A Donald D. Anthony
%A Elizabeth Zebrowski
%A Kelsey Rife
%A Lenche Kostadinova
%A Yngve Falck-Ytter
%J Archive of "Pathogens and Immunity".
%D 2018
%R 10.20411/pai.v3i1.242
%X During chronic hepatitis C virus (HCV) infection, Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) levels mark active liver inflammation and tissue damage, while albumin reflects synthetic liver function and nutritional status. Transient Elastography (TE) is a clinical measure of liver stiffness that facilitates evaluation of liver damage stage. While a portion of the TE score is attributable to liver fibrosis and relatively irreversible damage, another component of the TE score is attributable to liver inflammation or edema. Markers of inflammation during chronic HCV infection include soluble markers of immune activation, which are also associated with morbid outcome (including cardiovascular disease and liver-disease progression). Whether soluble markers of immune activation or changes in their level during HCV therapy relate to normalization of AST, ALT, Albumin, or TE score, is not clear
%K hepatitis C
%K cellular immunity
%K T cell
%K monocyte
%K inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201254/