%0 Journal Article
%T Positive impact of autophagy in human breast cancer cells on local immunosurveillance
%A David Enot
%A Guido Kroemer
%A Laura Senovilla
%A Laurence Zitvogel
%A Marie Chaix
%A Sylvain Ladoire
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2016.1174801
%X In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B+ puncta within malignant cells positively correlate with the intratumoral abundance of CD8+ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3+ regulatory T cells and CD68+ tumor-associated macrophages, resulting in an improvement of CD8+/FOXP+ or CD8+/CD68+ ratios
%K Autophagy
%K breast cancer
%K LC3
%K lymphocytes
%K macrophages
%K Treg cells.
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938361/