%0 Journal Article
%T Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism
%A Eduardo Arilla-Ferreiro
%A Emma Burgos-Ramos
%A Jes¨˛s Argente
%A Julie A. Chowen
%A Laura M. Frago
%A Sandra Canelles
%A Vicente Barrios
%J Archive of "Nutrition & Metabolism".
%D 2016
%R 10.1186/s12986-016-0079-9
%X Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulinĄ¯s hepatic actions. Since central leptin may modify insulin signaling in the liver, we hypothesized that leptin infusion activates hepatic glycogen synthesis following peripheral administration of a bolus of glucose or insulin, thus regulating glycemia
%K Glycemia
%K Glycogen synthesis
%K Insulin signaling
%K Leptin
%K Liver
%K Tolerance test
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774133/