%0 Journal Article
%T Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
%A Cheng Luo
%A Hao Jiang
%A Hao Zhang
%A Hong Ding
%A Hualiang Jiang
%A Jing Xing
%A Kaixian Chen
%A Liping Liao
%A Mingyue Zheng
%A Shijie Chen
%A Shijie Fan
%A Wei Chen
%A Yiqian Xie
%A Yiran Huang
%A Yuanyuan Zhang
%A Zhifeng Chen
%A Zhiyi Yao
%J Archive of "Oncogenesis".
%D 2018
%R 10.1038/s41389-018-0093-z
%X a Quantitative real-time PCR results of relative expression levels of BRD2, BRD3, BRD4 in 39 pairs of RCC tissues and adjacent normal tissues. b Immunoblot analysis of BRD2 and BRD4 expression in 6 pairs of RCC tissues and adjacent normal tissues. Quantifications are shown in the panels below. c Knockdown efficiency of siBRD2 and BRD4 by immunoblot analysis. d Knockdown of BRD2 or BRD4 moderately inhibited the proliferation of RCC 786-O and A498 cells, while knocking down both of their expressions resulted in more significant anti-proliferative effects. Two-way ANOVA with multiple comparisons was used to compare each knocking down group to siControl group. Representative results were shown, error bars indicated standard deviation among technical replicates (n£¿=£¿5 technical replicates per experiment). *p£¿<£¿0.05; **p£¿<£¿0.01; ***p£¿<£¿0.001. The experiments were replicated 3 times to confirm the conclusio
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212493/