%0 Journal Article
%T Improvement of immunogenic chemotherapy by STAT3 inhibition
%A Federico Pietrocola
%A Guido Kroemer
%A Heng Yang
%A Heng Zhou
%A Laurence Zitvogel
%A Takahiro Yamazaki
%A Yuting Ma
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1078061
%X The inhibition of STAT3 may exert cell-autonomous cytotoxic and cytostatic effects, yet may also stimulate anticancer immunosurveillance through the neutralization of immunosuppressive circuitries. In addition, STAT3 inhibition in cancer cells may stimulate the type 1 interferon response elicited by anthracyclines. This pathway results in an enhanced chemotherapy-associated anticancer immune response with improved therapeutic efficacy. Hence, combination therapies that include immunogenic cell death (ICD) inducers and STAT3 inhibitors can be envisaged
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801443/