%0 Journal Article
%T Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia
%A Anne Bordron
%A Audrey Mohr
%A Christophe Jamin
%A Cristina Bagacean
%A Jacques-Olivier Pers
%A Yves Renaudineau
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1132977
%X Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the identification of B regs and their role in CLL remain elusive. The aim of this review is to summarize recent works regarding the regulatory and phenotypic characteristic of B regs and their associated effects on the immune system. It is also meant to highlight their potential importance with regards to the immunotherapeutic response
%K B lymphocytes
%K CLL
%K immunotherapy
%K regulatory B cell
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910744/