%0 Journal Article
%T Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy
%A Juan R. Cubillos-Ruiz
%A Laurie H. Glimcher
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1098802
%X Cancers thrive under adverse conditions and simultaneously inhibit antitumor immunity. We recently found that endoplasmic reticulum (ER) stress responses driven by the IRE1¦Á-XBP1 pathway not only promote cancer cell survival, but also provoke severe dendritic cell (DC) dysfunction in tumors. Targeting IRE1¦Á-XBP1 represents a two-pronged approach to restrain malignant cells while eliciting concomitant antitumor immunity
%K Cancer immunotherapy
%K dendritic cells
%K IRE1
%K tumor immunology
%K tumor microenvironment
%K XBP1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839339/