%0 Journal Article
%T Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer
%A Jennifer Wu
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1095434
%X Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models
%K Cancer immunotherapy
%K NKG2D ligands
%K nonblocking sMIC-neutralizing anti-MIC antibody
%K soluble MIC
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839309/