%0 Journal Article
%T Attenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer
%A Barbara A. Fox
%A David J. Bzik
%A Kiah L. Sanders
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1104447
%X We have recently reported that treatment of disseminated pancreatic cancer with an attenuated Toxoplasma gondii uracil auxotroph vaccine promoted antitumor CD8+ T cell responses and long-term survival. Here, we optimized the treatment strategy for disseminated pancreatic cancer and show that attenuated Toxoplasma gondii therapy stimulated effective long-term immunity to pancreatic cancer through mechanisms involving CD4+ T cells and pancreatic tumor-specific IgG. Our results suggest that cell-mediated immunity in conjunction with humoral antibody immunity may offer greater resistance to recurrence of highly aggressive tumors. Cancer immunotherapeutic strategies using attenuated Toxoplasma gondii vaccines merit further investigation as a novel strategy to reawaken immunity to primary pancreatic carcinoma and to generate long-lasting immunity to pancreatic cancer recurrences
%K Humoral immunity
%K immunotherapy
%K pancreatic cancer
%K T cell protection
%K Toxoplasma gondii
%K tumor-specific antibodies
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839330/