%0 Journal Article
%T Ameliorating the tumor microenvironment for antitumor responses through TLR5 ligand-secreting T cells
%A Eduardo Davila
%A Sabina Kaczanowska
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1076609
%X Toll-like receptor (TLR) agonists are potent immunostimulatory agents that have demonstrated great potential for cancer immunotherapy. We have genetically-engineered tumor-specific T cells to deliver and secrete the TLR5 ligand (TLR5L) flagellin to the tumor site to provide costimulation for antitumor immune activity. We found that TLR5L-secreting T cells offered a therapeutic benefit by altering several aspects including augmenting T cell effector function and expansion as well as reshaping the tumor microenvironment toward one that enhances antitumor T cell responses
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839377/