%0 Journal Article
%T Interferon gamma/NADPH oxidase defense system in immunity and cancer
%A Jiri Bartek
%A Milan Reinis
%A Pavla Vasicova
%A Sona Hubackova
%A Zdenek Hodny
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1080416
%X As a part of cellular pathogen defense, IFN¦Ã triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFN¦Ã-mediated anticancer control. IFN¦Ã is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence
%K Cellular senescence
%K DNA damage response
%K oxidative stress
%K tumor growth factor beta
%K tumor immunosurveillance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801460/