%0 Journal Article
%T Breaking bad habits: Targeting MDSCs to alleviate immunosuppression in prostate cancer
%A Marcin Kortylewski
%A Sumanta K. Pal
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2015.1078060
%X The myeloid-derived suppressor cells (MDSCs) contribute to tumor immune evasion and still remain an elusive therapeutic target. Our study identified granulocytic MDSCs accumulating in prostate cancer patients during disease progression. We demonstrate the feasibility of using STAT3siRNA-based strategy for targeting MDSCs to alleviate arginase-dependent suppression of T cell activity
%K Arginase
%K immunotherapy
%K MDSC
%K myeloid-derived suppressor cells
%K prostate cancer
%K STAT3
%K TLR9
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801434/