%0 Journal Article
%T Effects of insulin and the glucagon©\like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice
%A James N. McGuire
%A Jenny Norlin
%A Leena Liljedahl
%A Peter James
%J Archive of "Physiological Reports".
%D 2017
%R 10.14814/phy2.13187
%X Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon©\like peptide 1 receptor (GLP©\1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin©\4 ¦Á©\carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor©\1¦Á (PCBD1), neural precursor cell expressed developmentally down©\regulated©\8 (NEDD8), transcription elongation factor©\B polypeptide©\1 (ELOC) and hepcidin (HEPC). Furthermore, the separation of the insulin, liraglutide and vehicle db/db mouse groups in multivariate analyses was not mainly related to the albumin excretion rate (AER) or the level of glycated hemoglobin A1c (HbA1c%) in the mice. In summary, we show that insulin and liraglutide give rise to separate protein profiles in the db/db mouse kidney
%K GLP©\1R agonist liraglutide
%K insulin
%K kidney proteome
%K OPLS©\DA
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371560/