%0 Journal Article
%T Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells
%A Adel Driss
%A Alexander Quarshie
%A Gale W. Newman
%A Jacqueline M. Hibbert
%A Jonathan K. Stiles
%A Karen R. Randall
%A Monica D.M. McGee
%A Racquel J. Wright
%A Zachary M. Kiser
%J Archive of "PeerJ".
%D 2017
%R 10.7717/peerj.3376
%X Chronic inflammation is a characteristic of sickle cell disease (SCD), and is invariably associated with vascular endothelial injury. Hydroxyurea (HU), a naturally cytotoxic chemotherapeutic agent, is the only FDA drug approved for SCD, and is therefore naturally cytotoxic. Quercetin (QCT) is a dietary flavonoid found ubiquitously in plants and foods that have anti-oxidative and anti-inflammatory characteristics. Our hypothesis is that dietary QCT will decrease cytotoxic effects of lipopolysaccharide (LPS) and HU induced vascular cell damage
%K Quercetin
%K Hydroxyurea
%K Sickle cell disease
%K Vascular endothelial cells
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455336/