%0 Journal Article
%T Acute effects of N©\terminal progastrin fragments on gastric acid secretion in man
%A Carsten P. Hansen
%A Jens F. Rehfeld
%A Jens P. Goetze
%J Archive of "Physiological Reports".
%D 2017
%R 10.14814/phy2.13164
%X We previously identified an N©\terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N©\terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1©\35 were infused intravenously during constant gastric acid stimulation by gastrin©\17. In addition, the effects of progastrin fragment 1©\35, fragment 6©\35, and fragment 1©\19 on gastrin©\17 stimulated acid secretion were tested. The gastrin©\17 stimulated acid secretion decreased 30% after administration of a high dose of progastrin fragment 1©\35 (P < 0.05). In extension, a 1©\h infusion of fragment 1©\35 also decreased gastric acid output. In contrast, fragment 6©\35 did not affect acid secretion, and a single infusion of gastrin©\17 alone did not reveal fading of gastric acid output during the time course of the experiments. The results show that N©\terminal fragments of progastrin may acutely affect gastrin©\stimulated gastric acid secretion in vivo. Structure©\function analysis suggests that the N©\terminal pentapeptide of progastrin is required for the effect
%K Acid secretion
%K inhibition
%K N©\terminal
%K progastrin
%K regulation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350173/