%0 Journal Article
%T Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases
%A Atsushi Kato
%A David Reza
%A Fredy Sussman
%A Juan C. Est¨¦vez
%A M. Carmen Villaverde
%A Marcos A. Gonz¨˘lez
%A Ram¨®n J. Est¨¦vez
%A Yuki Hirokami
%J Archive of "Pharmaceuticals".
%D 2019
%R 10.3390/ph12020047
%X Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases
%K sugars
%K iminosugars
%K glycosidase inhibition
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631223/