%0 Journal Article
%T Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System
%A Justyna Knapik-Kowalczuk
%A Karolina Jurkiewicz
%A Krzysztof Chmiel
%A Marian Paluch
%A Nat¨¢lia T. Correia
%A Wies£¿aw Sawicki
%J Archive of "Pharmaceuticals".
%D 2019
%R 10.3390/ph12010040
%X The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe¨Csimvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe¨Csimvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions (T = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated
%K ezetimibe
%K simvastatin
%K co-amorphous
%K melt viscosity
%K solubility enhancement
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469170/