%0 Journal Article
%T ¦Â2-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC
%A Christopher T. Lucido
%A Daniel W. Vermeer
%A Juan L. Callejas-Valera
%A Paola D. Vermeer
%A Paul L. Colbert
%A W. Keith Miskimins
%A William C. Spanos
%J Archive of "Oncogenesis".
%D 2018
%R 10.1038/s41389-018-0090-2
%X a Western blot analysis of ¦Â2AR expression in MLM3 and mEERL cell lines (top), and relative expression data (bottom), confirming upregulation in the recurrent/metastatic MLM3 model, as compared with the parental mEERL model from which it spontaneously derived (columns represent mean fold change in ¦Â2AR protein expression [normalized to ¦Â-actin loading control]£¿¡À£¿SEM from n£¿=£¿4 independent biological replicates; p-value reflects results of Mann¨CWhitney test). b Unfixed, unpermeabilized immunostaining of ¦Â2AR (red) on mEERL (left) and MLM3 (middle) cells showing membrane localization of the receptor (secondary antibody-only staining is shown in the right panel). Nuclei were stained with DAPI (blue). Top: overlay; bottom: ¦Â2AR onl
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175933/