%0 Journal Article
%T Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism
%A Feiruo Huang
%A Lulu Li
%A Ping Zhang
%A Zhengxi Bao
%J Archive of "Nutrition & Metabolism".
%D 2016
%R 10.1186/s12986-016-0090-1
%X The switching defective/sucrose non-fermenting (SWI/SNF) complexes play an important role in hepatic lipid metabolism regulating both transcriptional activation and repression. BAF60a is a core subunit of the SWI/SNF chromatin-remodeling complexes that activates the transcription of fatty acid oxidation genes during fasting/glucagon. BAF60c, another subunit of SWI/SNF complexes, is recruited to form the lipoBAF complex that activates lipogenic genes, promoting lipogenesis and increasing the triglyceride level in response to feeding/insulin. Interestingly, hepatocytes located in the periportal and perivenous zones of the liver display a remarkable heterogeneity in the activity of various enzymes, metabolic functions and gene expression. Especially, fatty-acid oxidation was shown to be mostly periportal, whereas lipogenesis was mostly perivenous. Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity
%K SWI/SNF complex
%K Chromatin remodeling
%K BAF60a
%K BAF60c
%K Lipid metabolism
%K Hepatocyte heterogeneity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848843/