%0 Journal Article
%T Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis
%A Eddy E. Owaga
%A I-Jong Tsai
%A Jeng-I Tsai
%A Pei-Chin Chung
%A Pei-Yuan Wang
%A Rong-Hong Hsieh
%A Shin-Yu Tsai
%A Tien-Shun Yeh
%J Archive of "Nutrition & Metabolism".
%D 2016
%R 10.1186/s12986-016-0148-0
%X Non-alcoholic fatty liver disease (NAFLD) is caused by multiple factors including hepatic oxidative stress, lipotoxicity, and mitochondrial dysfunction. Obesity is among the risk factors for NAFLD alongside type 2 diabetes mellitus and hyperlipidemia. ¦Á- mangostin (¦Á-MG) extracts from the pericarps of mangosteen (Garcinia mangostana Linn.) may regulate high fat diet-induced hepatic steatosis; however the underlying mechanisms remain unknown. The aim of this study was to investigate the regulatory effect of ¦Á-MG on high fat diet-induced hepatic steatosis and the underlying mechanisms related to mitochondrial functionality and apoptosis in vivo and in vitro
%K ¦Á-mangostin
%K Fat infiltration
%K Mitochondria dysfunction
%K Mitochondrial pathway apoptosis
%K Antioxidant enzymes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134003/