%0 Journal Article
%T Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling
%A A. K. Jonassen
%A A. Wergeland
%A E. A. Hoivik
%A F. Edland
%A K. Kristiansen
%A K. S. £¿srud
%A L. Madsen
%A M. Bakke
%A R. Kopperud
%A R. £¿s£¿y
%A S. L. Wits£¿
%A S. O. D£¿skeland
%J Archive of "Nutrition & Metabolism".
%D 2016
%R 10.1186/s12986-016-0147-1
%X Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the ¡°obesity paradox¡±. This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling
%K Myocardial ischemia
%K Reperfusion injury
%K PKA
%K Epac
%K cAMP
%K Infarct size
%K High fat diet
%K Cardiac function
%K Obesity
%K Heart
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127093/