%0 Journal Article
%T Muscle ion transporters and antioxidative proteins have different adaptive potential in arm than in leg skeletal muscle with exercise training
%A Giovanna Aquino
%A J¨¢kup A. Thomsen
%A Magni Mohr
%A Nikolai B. Nordsborg
%A Peter Krustrup
%A P¨¢l Weihe
%A Tobias Schmidt Nielsen
%J Archive of "Physiological Reports".
%D 2017
%R 10.14814/phy2.13470
%X It was evaluated whether upper©\body compared to lower©\body musculature exhibits a different phenotype in relation to capacity for handling reactive oxygen species (ROS), H+, La£¿, Na+, K+ and also whether it differs in adaptive potential to exercise training. Eighty©\three sedentary premenopausal women aged 45 ¡À 6 years (mean ¡À SD) were randomized into a high©\intensity intermittent swimming group (HIS, n = 21), a moderate©\intensity swimming group (MOS, n = 21), a soccer group (SOC, n = 21), or a control group (CON, n = 20). Intervention groups completed three weekly training sessions for 15 weeks, and pre©\ and postintervention biopsies were obtained from deltoideus and vastus lateralis muscle. Before training, monocarboxylate transporter 4 (MCT4), Na+/K+ pump ¦Á 2, and superoxide dismutase 2 (SOD2) expressions were lower (P < 0.05) in m. deltoideus than in m. vastus lateralis, whereas deltoid had higher (P < 0.05) Na+/H+ exchanger 1 (NHE1) expression. As a result of training, Na+/K+ pump ¦Á 2 isoform expression was elevated only in deltoideus muscle, while upregulation (P < 0.05) of the ¦Á 1 and ¦Â 1 subunits, phospholemman (FXYD1), NHE1, and superoxide dismutase 1 expression occurred exclusively in vastus lateralis muscle. The increased (P < 0.05) expression of MCT4 and SOD2 in deltoid muscle after HIS and vastus lateralis muscle after SOC were similar. In conclusion, arm musculature displays lower basal ROS, La£¿, K+ handling capability but higher Na+©\dependent H+ extrusion capacity than leg musculature. Training©\induced changes in the ion©\transporting and antioxidant proteins clearly differed between muscle groups
%K Acid/base regulation
%K antioxidant capacity
%K soccer
%K sodium/potassium pump
%K swimming
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641943/