%0 Journal Article
%T The combined effect of high©\intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults
%A Geraint Florida©\James
%A Hannah Margaret Lithgow
%A Melanie Leggate
%J Archive of "Physiological Reports".
%D 2018
%R 10.14814/phy2.13684
%X High©\intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ¡À 9 year; BMI, 31.4 ¡À 2.8 kg¡¤m£¿2) completed 6 weeks HIIT, and were randomized to ingest 100 ¦Ìg¡¤day©\1 of vitamin D3 or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ¡À 110 to 786 ¡À 139 mmol¡¤h£¿1¡¤L£¿1; P = 0.043) and insulin (8101 ¡À 4755¨C7024 ¡À 4489 mU¡¤h£¿1¡¤L£¿1; P = 0.049) area under the curve (AUC). Supplementation increased 25©\hydroxyvitamin D3 concentration by 120% to a sufficiency status (P < 0.001). However, the consumption of vitamin D3 seemed to attenuate the glucose response during an OGTT. Triglyceride content was lowered following the intervention (P = 0.025). There was no effect of the intervention on insulin sensitivity (IS) indices: ISIM atsuda and HOMA©\IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D3 supplementation did not proffer any additional positive effects on the measured indices of metabolic health
%K glucose tolerance
%K high©\intensity intermittent training
%K vitamin D
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925425/