%0 Journal Article
%T The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women
%A Dylan Thompson
%A James A. Betts
%A Jean©\Philippe Walhin
%A Natalie C. Dixon
%J Archive of "Physiological Reports".
%D 2016
%R 10.14814/phy2.13026
%X This study aimed to establish whether vigorous©\intensity exercise offers additional adipose©\related health benefits and metabolic improvements compared to energy©\matched moderate©\intensity exercise. Thirty©\eight sedentary overweight men (n = 24) and postmenopausal women (n = 14) aged 52 ¡À 5 years (mean ¡À standard deviations [SD]) were prescribed a 3©\week energy deficit (29302 kJ£¿week£¿1) achieved by increased isocaloric moderate or vigorous©\intensity exercise (+8372 kJ£¿week£¿1) and simultaneous restricted energy intake (£¿20930 kJ£¿week£¿1). Participants were randomly assigned to either an energy©\matched vigorous (VIG; n = 18) or moderate (MOD; n = 20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow©\up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Body mass was reduced similarly in both groups (£¿ 2.4 ¡À 1.1 kg and £¿ 2.4 ¡À 1.4 kg, respectively, P < 0.05). Insulinemic responses to a standard glucose load decreased similarly at follow©\up relative to baseline in VIG (£¿ 8.6 ¡À 15.4 nmol.120 min.l£¿1) and MOD (£¿ 5.4 ¡À 8.5 nmol.120 min.l£¿1; P < 0.05). Expression of SREBP©\1c and FAS in adipose tissue was significantly down©\regulated, whereas expression of PDK4 and hormone©\sensitive lipase (HSL) was significantly up©\regulated in both groups (P < 0.05). Thus, when energy expenditure and energy deficit are matched, vigorous or moderate©\intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression
%K Adipose tissue
%K energy restriction
%K exercise intensity
%K gene expression
%K metabolism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210391/