%0 Journal Article
%T Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin
%A Andi Dian Permana
%A Eneko Larra£¿eta
%A Ismaiel A. Tekko
%A Lalitkumar Vora
%A Ryan F. Donnelly
%A Sharif Abdelghany
%J Archive of "Pharmaceutics".
%D 2019
%R 10.3390/pharmaceutics11070308
%X The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of 11 ¡Á 11 microneedles of conical shape, measuring 900 ¦Ìm in height and with 300 ¦Ìm base diameter. The nanosuspension particle size was 520 ¡À 40 nm, with a polydispersity of 0.27 ¡À 0.02 using sodium lauryl sulfate (SLS) as a stabiliser. In vitro dissolution studies in 10% w/v Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from the CU-NS, compared to 16% from the curcumin powder after 48 h. The CU-NS-loaded microneedles (CU-MN) were able to withstand a compression force of 32 N for 30 s. Moreover, these microneedles were able to penetrate excised neonatal porcine skin to a depth of 500 ¦Ìm, dissolved completely in the skin within 60 min. After CU-MN dissolution, the drug diffused from the application site and migrated through the skin layers down to 2300 ¦Ìm, significantly more than observed with topical application of CU-NS. This suggest that the fabricated microneedles with the incorporated CU-NS could enhance the intradermal delivery of curcumin
%K curcumin
%K dissolving microneedles
%K intradermal
%K poly(vinylalcohol)
%K nanosuspension
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681049/